Purdy being listed as out adds pass-game uncertainty and may push the offense toward a heavier run or backup QB utilization. His absence could lower overall pass volume and elevate reliance on run game and short-yardage plays, affecting the entire SF offense’s fantasy projections.

Purdy’s turf-toe ends his run for several weeks, forcing Mac Jones into the starting role for the 49ers and prompting fantasy managers to consider streaming QBs like Daniel Jones, Trevor Lawrence, and Aaron Rodgers as longer-shot options.

Purdy sidelined by a toe issue creates a Week 2 quarterback domino effect for San Francisco. His absence elevates Mac Jones to the start and thrusts Adrian Martinez into active duties as emergency backup, highlighting the depth chart fragility and the opportunity for Martinez to showcase late-round grit.

Purdy toe/turf toe injury forces Week 2 absence; Mac Jones starts, with Purdy potentially back in Week 4–5. Pearsall remains a WR2; Jennings a WR3; long-term Purdy’s rushing upside keeps him in low-end QB1 territory when healthy.

Injury status: turf toe/toe; ruled out Week 2; offense relies on Mac Jones and CMC.